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Giuseppe Agosta

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da P. Zerbi

Male infertility and ageing: two faces of the same coin?
A. Alfano  |  M. Nebuloni  |  P. Zerbi  |  A. Salonia  | 
<p>Couple infertility has become a common condition in Western societies, with important medical, psychological and socio-economical consequences. Female conditions related to infertility have been extensively investigated. On the contrary, despite infertility affects 7% of all men and 50% of cases are of idiopathic nature, there is still a lack in terms of knowledge about etiology and pathophysiology behind male factor infertility. Clinically, infertile men are sicker than fertile men, as they experience higher rate of developing neoplastic disease and age-related comorbidities. Moreover, histological modifications of testicular parenchima of elder men are very similar to that observed in younger infertile male. Thereof, infertile male could be considered as an individual characterized by a faster ageing process. As a whole, a poorer health status appears to be associated to a malfunctioning male reproductive system, with the worst clinical picture in azoospermic individuals. We could considerate that an infertile male is an individual who grows old sooner and speculate that the same mechanisms leading to clinical and testicular histopathological modification of the elder lead to infertility in the young man. On the whole, male infertility could be considered as a proxy of general male health, with the etiological factors for infertility possibly representing markers of male healthiness and therapeutic intervention. Better understanding of the pathological bases of one condition could lighten the comprehension of the other one.</p>
Biochimica Clinica ; 41(4) 364-367
Opinioni - Opinions